Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPN | P05981 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603987 | 0.87 | ALOX15 (0.55) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9328163 | 0.83 | HPN (0.47) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9168126 | 0.83 | ALOX15 (0.50) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9681551 | 0.83 | ALOX15 (0.50) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9484852 | 0.83 | ALOX15 (0.50) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL11605148 | 0.81 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9384054 | 0.81 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9466902 | 0.81 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL9550808 | 0.80 | ALOX15 (0.47) | ALOX15MAPTHPNSIRT5CA2 | |
| SCHEMBL5692187 | 0.79 | ALOX15 (0.63) | ALOX15MAPTHPNSIRT5CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | disclosed |
| US-4711903-A | ANTIINFLAMMATORY, ANTIALLERGY AGENTS | G. D. SEARLE & CO. (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0235575-A1 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1987-09-09 | — | — | EP | disclosed |
| EP-0060799-B1 | DIESTER ANTIOXIDANTS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1984-06-06 | — | — | EP | disclosed |
| US-4394476-A | POLYMERS, BUTADIENE-STYRENE COPOLYMER | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1983-07-19 | — | — | US | disclosed |
| EP-0060799-A1 | Diester antioxidants | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1982-09-22 | — | — | EP | disclosed |