Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603987 | 0.91 | ALOX15 (0.55) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9384054 | 0.85 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL10685089 | 0.83 | ALOX15 (0.53) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL10356707 | 0.80 | VCAM1 (0.44) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL11603068 | 0.79 | ALOX15 (0.42) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL11605148 | 0.79 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9466902 | 0.79 | ALOX15 (0.49) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9507433 | 0.78 | MAPT (0.61) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9735154 | 0.78 | VCAM1 (0.48) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9350056 | 0.78 | VCAM1 (0.43) | ALOX15MAPTHPNSIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547090-A1 | PHENOLIC THIOETHERAMIDES AS 5-LIPOXYGENASE INHIBITORS. | SEARLE & CO (US) | 1993-06-23 | — | — | EP | disclosed |
| WO-1992004324-A1 | PHENOLIC THIOETHERAMIDES AS 5-LIPOXYGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1992-03-19 | — | — | WO | disclosed |