Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9492905 | 0.87 | ALOX15 (0.47) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL646924 | 0.84 | ALOX15 (0.63) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9701565 | 0.83 | HPN (0.44) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9701236 | 0.83 | ALOX15 (0.44) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL10685089 | 0.83 | ALOX15 (0.53) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9621562 | 0.83 | ALOX15 (0.46) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9621875 | 0.81 | VCAM1 (0.43) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9494838 | 0.81 | MAPT (0.47) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL8702044 | 0.80 | ALOX15 (0.59) | ALOX15HPNMAPTSIRT5CA2 | |
| SCHEMBL9701573 | 0.80 | HPN (0.44) | ALOX15HPNMAPTSIRT5CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547090-B1 | PHENOLIC THIOETHERAMIDES AS 5-LIPOXYGENASE INHIBITORS | SEARLE & CO (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5342838-A | Antiallergens, emzyme inhibitors, antihistamine, skin disorder | G. D. SEARLE & CO. (US) | 1994-08-30 | — | — | US | disclosed |
| US-5326907-A | 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers | G. D. SEARLE & CO. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5298514-A | Antiinflammatory agents or antiallergens | G. D. SEARLE & CO. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5229421-A | Antiallergens, antiinflammatory agents | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| WO-1992019591-A1 | PROCESS FOR PREPARATION OF ALPHA-ALKOXY ACETIC ACIDS AND THEIR SALTS | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512472-A1 | Process for preparation of alpha-alkoxy acetic acids and their salts | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-5145992-A | Oxyalkylation of an alcohol, reaction with monoaloacetic acid and then with hydrochloic acid | G. D. SEARLE & CO. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5064860-A | Disease therapy | G. D. SEARLE & CO. (US) | 1991-11-12 | — | — | US | disclosed |
| US-5047593-A | Antiinflammatory And Antiallergy Agents | G. D. SEARLE & CO. (US) | 1991-09-10 | — | — | US | disclosed |
| US-5013864-A | From alcohol and haloacetic acid salt | G. D. SEARLE & CO. (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0218782-B1 | LIPOXYGENASE-INHIBITING COMPOSITION AND HYDROXYPHENYLTHIOALKYLCARBONYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-16 | — | — | EP | disclosed |
| US-4857558-A | ANTIINFLAMMATORY AGENTS AND-OR ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1989-08-15 | — | — | US | disclosed |