Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 12/20 | 0.44 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.42 |
| ▸ | GLRB | P48167 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685089 | 0.83 | ALOX15 (0.53) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10677513 | 0.83 | VCAM1 (0.42) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL11603987 | 0.82 | ALOX15 (0.55) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9707067 | 0.79 | KDM4E (0.42) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10769689 | 0.79 | HMGCR (0.54) | MAPTALOX15GLRA3GLRBCA2 | |
| SCHEMBL1278385 | 0.79 | HMGCR (0.54) | MAPTALOX15GLRA3GLRBCA2 | |
| SCHEMBL9350056 | 0.79 | VCAM1 (0.43) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9735154 | 0.79 | VCAM1 (0.48) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9621875 | 0.79 | VCAM1 (0.43) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10356707 | 0.78 | VCAM1 (0.44) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | claimed |
| EP-0079855-A1 | Alkylated hydroxyphenylthioalcanoic esters | CIBA-GEIGY AG (CH) | 1983-05-25 | — | — | EP | disclosed |