Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.51 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688714 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL30228827 | 0.76 | EGFR (0.43) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL22324121 | 0.76 | EGFR (0.43) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL10686873 | 0.76 | TDP2 (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10567082 | 0.74 | MEN1 (0.47) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL10688603 | 0.73 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10842926 | 0.73 | ALDH1A1 (0.46) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL12962009 | 0.73 | SYK (0.66) | SYK | |
| SCHEMBL10688346 | 0.73 | KDM4E (0.51) | PDE4APDE4BPDE4CPDE4DSYK | |
| SCHEMBL15345108 | 0.72 | RAB9A (0.56) | PDE4APDE4BPDE4CPDE4DFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |