Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685215 | 0.93 | CASP6 (0.43) | CASP6ALDH1A1CYP11B2CYP11B1KDM4E | |
| SCHEMBL10685000 | 0.88 | MAPT (0.39) | ALDH1A1MAPTPOLBBCL2A1MAPK1 | |
| SCHEMBL10688219 | 0.87 | ALDH1A1 (0.43) | ALDH1A1CYP11B2KDM4ESMN1; SMN2MAPT | |
| SCHEMBL10686019 | 0.86 | CACNA2D1 (0.41) | ALDH1A1MAPTL3MBTL1HTTKMT2A | |
| SCHEMBL10682185 | 0.85 | SCN2A (0.49) | ALDH1A1KDM4EMAPTL3MBTL1HTT | |
| SCHEMBL10687000 | 0.81 | TSHR (0.40) | ALDH1A1MAPTPOLBTSHRBCL2A1 | |
| SCHEMBL10681336 | 0.80 | ALDH1A1 (0.43) | ALDH1A1CYP11B2KDM4ESMN1; SMN2MAPT | |
| SCHEMBL10688176 | 0.79 | CACNA2D1 (0.43) | ALDH1A1MAPTL3MBTL1KMT2AMGLL | |
| SCHEMBL10685053 | 0.78 | SCN2A (0.51) | ALDH1A1KDM4EMAPTL3MBTL1HTT | |
| SCHEMBL10684358 | 0.77 | CYP11B2 (0.49) | ALDH1A1CYP11B2CYP11B1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220282-A1 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1987-05-06 | — | — | EP | claimed |
| WO-1986006375-A2 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1986-11-06 | — | — | WO | claimed |
| US-4725596-A | Pyrimidine derivatives having anti-allergy, anti-inflammatory and immuno suppressant activity | SCHERING CORPORATION (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0220282-A1 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |
| WO-1986006375-A2 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1986-11-06 | — | — | WO | disclosed |