Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688176 | 0.94 | CACNA2D1 (0.43) | CACNA2D1MAPTNPC1MGLLALDH1A1 | |
| SCHEMBL10685804 | 0.86 | CASP6 (0.42) | MAPTMGLLALDH1A1HTTKMT2A | |
| SCHEMBL10688219 | 0.84 | ALDH1A1 (0.43) | CACNA2D1MAPTNPC1ALDH1A1HTT | |
| SCHEMBL10682185 | 0.82 | SCN2A (0.49) | MAPTALDH1A1HTTKMT2AL3MBTL1 | |
| SCHEMBL10685000 | 0.81 | MAPT (0.39) | MAPTNPC1LMNAALDH1A1KAT2B | |
| SCHEMBL10685215 | 0.79 | CASP6 (0.43) | MAPTMGLLALDH1A1HTTKMT2A | |
| SCHEMBL10681336 | 0.77 | ALDH1A1 (0.43) | CACNA2D1MAPTNPC1LMNAALDH1A1 | |
| SCHEMBL10685053 | 0.76 | SCN2A (0.51) | MAPTALDH1A1HTTKMT2AL3MBTL1 | |
| SCHEMBL10684358 | 0.74 | CYP11B2 (0.49) | MAPTALDH1A1HTTL3MBTL1 | |
| SCHEMBL10687000 | 0.74 | TSHR (0.40) | MAPTNPC1LMNAALDH1A1KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220282-A1 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1987-05-06 | — | — | EP | claimed |
| WO-1986006375-A2 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1986-11-06 | — | — | WO | claimed |
| US-4725596-A | Pyrimidine derivatives having anti-allergy, anti-inflammatory and immuno suppressant activity | SCHERING CORPORATION (US) | 1988-02-16 | — | — | US | disclosed |
| EP-0220282-A1 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1987-05-06 | — | — | EP | disclosed |
| WO-1986006375-A2 | PYRIMIDINE DERIVATIVES HAVING ANTI-ALLERGY, ANTI-INFLAMMATORY AND IMMUNO SUPPRESSANT ACTIVITY | SCHERING CORPORATION (US) | 1986-11-06 | — | — | WO | disclosed |