Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278725 | 0.86 | RAB9A (0.43) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL2637165 | 0.84 | RAB9A (0.44) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL10550339 | 0.76 | KDM4E (0.38) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL2031522 | 0.75 | SYK (0.38) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL11446404 | 0.74 | HTR2C (0.39) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL1193460 | 0.74 | HDAC6 (0.48) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL30937347 | 0.73 | RAB9A (0.42) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL29937801 | 0.73 | L3MBTL1 (0.44) | RAB9AMAPTHDAC6HDAC1HDAC2 | |
| SCHEMBL6179196 | 0.72 | RAB9A (0.41) | RAB9AMAPTHDAC6CCR1CCR5 | |
| SCHEMBL842552 | 0.72 | CCR1 (0.50) | RAB9AMAPTHDAC6CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |