Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688273 | 0.89 | PDE2A (0.35) | AURKATYK2JAK3KMT2APDE2A | |
| SCHEMBL10686151 | 0.84 | EGFR (0.35) | AURKATYK2JAK3CDC7PLK4 | |
| SCHEMBL10687815 | 0.82 | EGFR (0.37) | AURKATYK2JAK3CDC7PLK4 | |
| SCHEMBL10691918 | 0.80 | PKM (0.38) | AURKAFGFR1KMT2APDE2APDE5A | |
| SCHEMBL10686344 | 0.78 | JAK3 (0.35) | AURKATYK2JAK3CDC7PLK4 | |
| SCHEMBL10690472 | 0.77 | PDE2A (0.43) | AURKAKMT2APDE2APDE5AMEN1 | |
| SCHEMBL10690518 | 0.74 | AMY1A (0.47) | AURKAKMT2APDE2APDE5AMEN1 | |
| SCHEMBL10688260 | 0.74 | NR1I2 (0.34) | DYRK1ADYRK1BKMT2ASMN1; SMN2MEN1 | |
| Water SCHEMBL10869421 | 0.72 | PDE2A (0.47) | AURKAPDGFRBPDGFRAKMT2APDE2A | |
| Water SCHEMBL10868986 | 0.72 | PDE2A (0.47) | AURKAPDGFRBPDGFRAKMT2APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |