Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688260 | 0.89 | NR1I2 (0.34) | DYRK1ADYRK1BKMT2ASMN1; SMN2PTGES | |
| SCHEMBL10686159 | 0.84 | AURKA (0.35) | EGFRKDRDYRK1ADYRK1BCDC7 | |
| SCHEMBL10691911 | 0.81 | PKM (0.38) | CYP1A2 | |
| SCHEMBL10690462 | 0.78 | AMY1A (0.40) | SMN1; SMN2POLBAMY1AALDH1A1KDM4E | |
| SCHEMBL10687815 | 0.77 | EGFR (0.37) | EGFRKDRDYRK1ADYRK1BCDC7 | |
| SCHEMBL10690513 | 0.75 | AMY1A (0.47) | PDGFRBPDGFRAMAPK1MAPK8MAPK9 | |
| SCHEMBL10686344 | 0.75 | JAK3 (0.35) | EGFRKDRDYRK1ADYRK1BCDC7 | |
| SCHEMBL10688273 | 0.72 | PDE2A (0.35) | AURKATYK2JAK3KMT2ANR1I2 | |
| SCHEMBL10690574 | 0.72 | PDE2A (0.51) | MAPK1AMY1AALDH1A1KDM4EGAA | |
| SCHEMBL10870043 | 0.71 | MAPT (0.37) | DYRK1ADYRK1BPTGESMAPTAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |