Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.47 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.47 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.47 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.47 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.47 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.47 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.47 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870372 | 1.00 | PTGES (0.50) | PTGESSIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL31189307 | 1.00 | PTGES (0.50) | PTGESSIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL8257100 | 0.87 | TBXAS1 (0.53) | PLA2G10PLA2G2APLA2G1BPLA2G5PLA2G2C | |
| SCHEMBL3471743 | 0.84 | HCAR2 (0.47) | PTGESSIGMAR1NPC1RAB9AFFAR1 | |
| SCHEMBL25173384 | 0.83 | TSHR (0.51) | PTGESSIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL6029226 | 0.83 | FFAR1 (0.67) | FFAR1MAOB | |
| SCHEMBL1124990 | 0.83 | PLA2G10 (0.47) | MEN1NPC1RAB9AKMT2APLA2G10 | |
| SCHEMBL27785183 | 0.82 | HCAR2 (0.46) | PTGESSIGMAR1NPC1RAB9AFFAR1 | |
| SCHEMBL18367812 | 0.82 | ALDH1A1 (0.49) | PTGESSIGMAR1MEN1NPC1RAB9A | |
| SCHEMBL27641743 | 0.82 | ALDH1A1 (0.49) | PTGESSIGMAR1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112930347-A | Inhibitors of KEAP1-Nrf2 protein-protein interactions | 詹森药业有限公司 | 2021-06-08 | — | — | CN | disclosed |
| US-4738803-A | ENZYME INHIBITORS | ROQUES BERNARD (FR) | 1988-04-19 | — | — | US | disclosed |
| US-4618708-A | ENKEPHALINASE INHIBITOR, ANALGESICS, ANTIDEPRESSANT, ANTIDIARRHEA, OR HYPOTENSIVE AGENT | ROQUES BERNARD (FR) | 1986-10-21 | — | — | US | disclosed |