Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686542 | 0.83 | SRD5A1 (0.37) | LMNAPARP1CHEK1TYMSDDB1 | |
| SCHEMBL10379371 | 0.83 | SRD5A1 (0.37) | LMNATYMSDDB1CRBNALDH1A1 | |
| SCHEMBL7594487 | 0.79 | CYP11B1 (0.42) | LMNAPARP1HSD17B10DDB1CRBN | |
| SCHEMBL10689555 | 0.77 | CYP1A2 (0.36) | TYMSDDB1CRBN | |
| SCHEMBL10687008 | 0.75 | ACHE (0.38) | HSD17B10ALDH1A1ACHE | |
| SCHEMBL10685831 | 0.74 | CYP19A1 (0.35) | CHEK1PIM1TYMSDDB1CRBN | |
| SCHEMBL10377999 | 0.74 | SRD5A1 (0.40) | PARP1CHEK1TYMSDDB1CRBN | |
| SCHEMBL10689321 | 0.74 | ABL1 (0.39) | LMNATYMSHSD17B10KDM4EALDH1A1 | |
| SCHEMBL21827508 | 0.68 | CYP19A1 (0.36) | DDB1CRBN | |
| SCHEMBL14494399 | 0.67 | PDE3A (0.36) | LMNADDB1CRBNKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | claimed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |