Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686873 | 0.75 | TDP2 (0.49) | TDP2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10689891 | 0.72 | PDE4B (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL15032575 | 0.70 | TDP2 (1.00) | TDP2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL16266535 | 0.70 | L3MBTL1 (0.53) | TDP2KDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL11188283 | 0.69 | AGTR1 (0.53) | TDP2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10690098 | 0.69 | L3MBTL1 (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL11577680 | 0.69 | KDM4E (0.47) | TDP2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11187171 | 0.69 | AGTR1 (0.52) | TDP2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31276986 | 0.69 | SMN1; SMN2 (0.57) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL14893220 | 0.69 | ADORA2A (0.60) | HSD17B10THRBPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |