Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688386 | 0.83 | FASN (0.47) | IDH1PIM1PIM2DHODHEGLN2 | |
| SCHEMBL10690944 | 0.82 | EGLN2 (0.39) | IDH1PIM1CSNK2A2CSNK2BPIM3 | |
| SCHEMBL5651808 | 0.77 | RHEB (0.61) | AMY1AMEN1KMT2A | |
| SCHEMBL10690686 | 0.74 | EGLN2 (0.39) | IDH1EGLN2PDE5ACYP11B1CYP11B2 | |
| SCHEMBL10673698 | 0.73 | PDE5A (0.48) | EGLN2PDE5ACYP11B1CYP11B2AMY1A | |
| SCHEMBL10687648 | 0.73 | ADORA2B (0.44) | IDH1EGLN2MAPK10CYP11B1CYP11B2 | |
| SCHEMBL10742540 | 0.71 | PDE2A (0.70) | PDE5APDE2APDE3BPDE3AKDM4E | |
| SCHEMBL10745392 | 0.70 | PDE2A (0.47) | EGLN2PDE5ACYP11B1CYP11B2PDE2A | |
| SCHEMBL10373620 | 0.70 | PDE3B (0.48) | MAPK10PDE5AAMY1APDE3BPDE3A | |
| SCHEMBL10692684 | 0.69 | ADORA2B (0.46) | DHODHPDE5AAMY1APDE2APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |