Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691571 | 0.82 | PDE2A (0.41) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL10689310 | 0.79 | MKNK1 (0.47) | LRRK2 | |
| SCHEMBL10692555 | 0.79 | CA2 (0.43) | PDE2ACCNT1CDK9PDE5APDE3B | |
| SCHEMBL10690895 | 0.78 | TAS2R14 (0.40) | PDE2ASCN9APDE5APDE3BPDE3A | |
| SCHEMBL10686293 | 0.77 | GRIN2D (0.42) | PDE2AGRIN1GRIN2BPDE5APDE3B | |
| SCHEMBL10692548 | 0.77 | MAPT (0.46) | PDE2APDE5APDE3BPDE3AKDM4E | |
| SCHEMBL10690944 | 0.76 | EGLN2 (0.39) | EGLN2CYP11B1CYP11B2PDE2AIDH1 | |
| SCHEMBL10673698 | 0.76 | PDE5A (0.48) | EGLN2CYP11B1CYP11B2PDE2APDE5A | |
| SCHEMBL10687648 | 0.76 | ADORA2B (0.44) | EGLN2CYP11B1CYP11B2SCN9ACCNT1 | |
| SCHEMBL10745392 | 0.76 | PDE2A (0.47) | EGLN2CYP11B1CYP11B2PDE2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |