Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688386 | 0.83 | FASN (0.47) | EGLN2CYP11B1CYP11B2IDH1MAPK10 | |
| SCHEMBL10692684 | 0.83 | ADORA2B (0.46) | PDE5APDE3BPDE3ADHODHPDE2A | |
| SCHEMBL10688606 | 0.83 | PDE7A (0.48) | PDE5APDE3BPDE3ADHODHPARP1 | |
| SCHEMBL10693845 | 0.83 | GAA (0.43) | PDE5APDE3BPDE3ADHODHPARP1 | |
| SCHEMBL10688693 | 0.82 | IDH1 (0.42) | EGLN2CYP11B1CYP11B2IDH1MAPK10 | |
| SCHEMBL10688582 | 0.81 | PDE5A (0.38) | PDE5APDE3BPDE3ADHODHPARP1 | |
| SCHEMBL10686161 | 0.80 | CDK4 (0.42) | CYP11B1CYP11B2PDE5APDE3BPDE3A | |
| SCHEMBL10869682 | 0.79 | KDM4E (0.43) | PDE5ADHODHPARP1PDE2AKDM4E | |
| SCHEMBL10691563 | 0.79 | CA2 (0.42) | PDE5APDE3BPDE3ADHODHPARP1 | |
| SCHEMBL10686472 | 0.79 | PDE5A (0.37) | PDE5APDE3BPDE3ADHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |