P-Xylene

P-Xylene

SCHEMBL10690560

Cc1ccc(C)cc1.O=P([O-])([O-])[O-].[Na+].[Na+].[Na+]

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of P-Xylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
HPGD P15428 1/20 0.52
LMNA P02545 3/20 0.50
TSHR P16473 2/20 0.50
CYP3A4 P08684 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
GAA P10253 3/20 0.48
ALDH1A1 P00352 3/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HSD17B10 Q99714 1/20 0.43
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA3 P07451 1/20 0.43
CA6 P23280 1/20 0.43
CA5A P35218 1/20 0.43
CA7 P43166 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
P-Xylene SCHEMBL28237278 0.97 LMNA (0.52) ACHETDP1HPGDLMNATSHR
P-Cresol SCHEMBL8464882 0.87 ACHE (0.65) ACHETDP1HPGDLMNATSHR
P-Cresol SCHEMBL9785887 0.87 ACHE (0.65) ACHETDP1HPGDLMNATSHR
Toluene SCHEMBL27535892 0.85 LMNA (0.61) ACHEHPGDLMNATSHRMEN1
SCHEMBL11024290 0.83 HPGD (0.56) ACHETDP1HPGDLMNATSHR
Phosphoric Acid SCHEMBL27842736 0.83 HPGD (0.44) ACHETDP1HPGDLMNATSHR
P-Cresol SCHEMBL10686122 0.81 ACHE (0.65) ACHETDP1HPGDLMNATSHR
P-Cresol SCHEMBL11677207 0.81 ACHE (0.65) ACHETDP1HPGDLMNATSHR
Toluene SCHEMBL28803471 0.79 LMNA (0.61) ACHEHPGDLMNATSHRCYP3A4
Toluene SCHEMBL1931899 0.79 LMNA (0.61) ACHEHPGDLMNATSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4776974-A MIXTURE WITH MONO-(OR DI)CARBOXYLIC ACID DIVERSEY WYANDOTTE CORPORATION (US) 1988-10-11 US disclosed
US-4715980-A FOOD PREPARATION AND HANDLING EQUIPMENT DIVERSEY WYANDOTTE CORPORATION (US) 1987-12-29 US disclosed