Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | GRM6 | O15303 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10109209 | 0.84 | ALOX5 (0.42) | ALOX5GRM6CHEK1AKT2MAPT | |
| SCHEMBL13713793 | 0.82 | GRM6 (0.47) | ALOX5GRM6LIMK1MAPTHTT | |
| SCHEMBL13093559 | 0.82 | CHEK1 (0.42) | CHEK1AKT2MAPTHTTALDH1A1 | |
| SCHEMBL26724795 | 0.77 | ALOX5 (0.40) | ALOX5GRM6CHEK1AKT2LIMK1 | |
| SCHEMBL21494935 | 0.77 | GRM6 (0.49) | ALOX5GRM6LIMK1MAPTHTT | |
| SCHEMBL1224397 | 0.76 | MAPT (0.56) | ALOX5GRM6CHEK1AKT2MAPT | |
| SCHEMBL12262883 | 0.74 | ALOX5 (0.51) | ALOX5GRM6CHEK1AKT2MAPT | |
| SCHEMBL13337266 | 0.74 | AKT2 (0.46) | ALOX5CHEK1AKT2MAPTHTT | |
| SCHEMBL16996824 | 0.74 | GRM6 (0.52) | ALOX5GRM6LIMK1MAPTHTT | |
| SCHEMBL10698380 | 0.72 | ALOX5 (0.48) | ALOX5GRM6LIMK1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4749712-A | Antiinflammatory and/or analgesic 5-alkylthiophenes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-06-07 | — | — | US | disclosed |