Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691961 | 0.88 | ADORA2B (0.42) | CYP3A4ALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL10691998 | 0.84 | ADORA2B (0.42) | CYP3A4ALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL10609116 | 0.81 | KDM4E (0.45) | CYP3A4ALDH1A1HPGDHSD17B10ADORA2B | |
| SCHEMBL10685583 | 0.81 | SMN1; SMN2 (0.44) | CYP3A4ALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL10686225 | 0.80 | MKNK1 (0.46) | CYP3A4HSD17B10MAPK1ADORA2BFGFR1 | |
| SCHEMBL10687648 | 0.78 | ADORA2B (0.44) | CYP3A4HSD17B10ADORA2BFGFR1FGFR2 | |
| SCHEMBL10688369 | 0.78 | ADORA2B (0.47) | CYP3A4CA2CA9CA12CA1 | |
| SCHEMBL10688379 | 0.78 | FGFR1 (0.45) | CYP3A4CA2CA9CA12CA1 | |
| SCHEMBL10692555 | 0.76 | CA2 (0.43) | ALDH1A1HPGDHSD17B10CA2CA9 | |
| SCHEMBL10694024 | 0.75 | KDM4E (0.71) | CYP3A4ALDH1A1HPGDHSD17B10ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |