Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690657 | 0.84 | CYP3A4 (0.49) | ADORA2BHSD17B10CYP3A4ALDH1A1HPGD | |
| SCHEMBL10687750 | 0.78 | PKM (0.39) | CYP3A4PKMKDM4EPDE3BPDE3A | |
| SCHEMBL10685583 | 0.78 | SMN1; SMN2 (0.44) | ADORA2BHSD17B10CYP3A4ALDH1A1HPGD | |
| SCHEMBL10609116 | 0.76 | KDM4E (0.45) | ADORA2BHSD17B10CYP3A4ALDH1A1HPGD | |
| SCHEMBL10691961 | 0.76 | ADORA2B (0.42) | ADORA2BHSD17B10CYP3A4ALDH1A1HPGD | |
| SCHEMBL10681085 | 0.75 | METAP2 (0.41) | HSD17B10ALDH1A1HPGDPKMFGFR1 | |
| SCHEMBL10686225 | 0.74 | MKNK1 (0.46) | ADORA2BHSD17B10CYP3A4MAPK1FGFR1 | |
| SCHEMBL10688852 | 0.74 | ADORA2B (0.45) | ADORA2BHSD17B10CYP3A4MAPK1PKM | |
| SCHEMBL10688369 | 0.73 | ADORA2B (0.47) | ADORA2BCYP3A4FGFR1FGFR2ENPP1 | |
| SCHEMBL10687648 | 0.73 | ADORA2B (0.44) | ADORA2BHSD17B10CYP3A4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |