Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690743 | 0.90 | TSHR (0.51) | ALDH1A1TP53ABL1RIN1TSHR | |
| SCHEMBL10523492 | 0.89 | LMNA (0.51) | ALDH1A1TSHRL3MBTL1SMN1; SMN2HCRTR1 | |
| SCHEMBL10571732 | 0.89 | LMNA (0.51) | ALDH1A1TSHRL3MBTL1SMN1; SMN2HCRTR1 | |
| SCHEMBL10571411 | 0.89 | LMNA (0.51) | ALDH1A1TSHRL3MBTL1SMN1; SMN2HCRTR1 | |
| SCHEMBL10688334 | 0.87 | ALDH1A1 (0.53) | ALDH1A1TSHRGAAHCRTR1HCRTR2 | |
| SCHEMBL14443191 | 0.87 | LMNA (0.49) | ALDH1A1TP53TSHRALOX15SMN1; SMN2 | |
| SCHEMBL10691297 | 0.85 | ABL1 (0.46) | ALDH1A1TP53ABL1RIN1TSHR | |
| SCHEMBL10571455 | 0.83 | LMNA (0.58) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10573892 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TSHRMDM2L3MBTL1 | |
| SCHEMBL10689204 | 0.81 | HPGD (0.50) | ALDH1A1TP53TSHRMDM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | claimed |