Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574313 | 0.85 | HDAC6 (0.56) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10690718 | 0.85 | ALDH1A1 (0.55) | ABL1RIN1TSHRALDH1A1ALOX15 | |
| SCHEMBL10571455 | 0.85 | LMNA (0.58) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10571732 | 0.85 | LMNA (0.51) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10571411 | 0.85 | LMNA (0.51) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10523492 | 0.85 | LMNA (0.51) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10572271 | 0.84 | MEN1 (0.44) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL14443191 | 0.77 | LMNA (0.49) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10575026 | 0.76 | MAPT (0.58) | HDAC1HDAC8HDAC6HDAC5TSHR | |
| SCHEMBL10692803 | 0.76 | MAPT (0.51) | HDAC1HDAC8HDAC6HDAC5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-87107226-A | Lactam derivatives and preparation thereof | — | 1988-06-29 | — | — | CN | claimed |
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | claimed |