Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690718 | 0.90 | ALDH1A1 (0.55) | TSHRALDH1A1SMN1; SMN2ABL1TP53 | |
| SCHEMBL10571602 | 0.84 | LMNA (0.60) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10523492 | 0.84 | LMNA (0.51) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10571732 | 0.84 | LMNA (0.51) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10571411 | 0.84 | LMNA (0.51) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10688334 | 0.83 | ALDH1A1 (0.53) | TSHRALDH1A1GAAKMT2A | |
| SCHEMBL14443191 | 0.82 | LMNA (0.49) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10571455 | 0.79 | LMNA (0.58) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10692803 | 0.79 | MAPT (0.51) | TSHRHDAC1HDAC6ALDH1A1LMNA | |
| SCHEMBL10573892 | 0.78 | ALDH1A1 (0.51) | TSHRHDAC1HDAC6ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | claimed |