Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601015 | 0.79 | MEN1 (0.44) | HTR1ADRD2CCR5MEN1KMT2A | |
| SCHEMBL10686650 | 0.78 | HTR1A (0.50) | HTR1ADRD2CCR5MEN1KMT2A | |
| SCHEMBL10683573 | 0.76 | HTR1A (0.48) | HTR1ADRD2CCR5MEN1KMT2A | |
| SCHEMBL8601204 | 0.75 | CCR5 (0.45) | HTR1ADRD2CCR5MEN1KMT2A | |
| SCHEMBL5940792 | 0.74 | MEN1 (0.40) | HTR1ADRD2CCR5MEN1KMT2A | |
| SCHEMBL27252708 | 0.74 | MAPT (0.44) | HTR1ACCR5MEN1KMT2AALDH1A1 | |
| SCHEMBL11895434 | 0.73 | HTR1A (0.47) | HTR1ADRD2MEN1KMT2AALDH1A1 | |
| SCHEMBL772662 | 0.73 | KDM4C (0.47) | HTR1ACCR5MEN1KMT2AALDH1A1 | |
| SCHEMBL10691066 | 0.73 | DHFR (0.39) | HTR1ACCR5MEN1KMT2AALDH1A1 | |
| SCHEMBL8350940 | 0.72 | MEN1 (0.50) | HTR1ACCR5MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |