Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 9/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690683 | 0.79 | TSHR (0.43) | KCNH2LMNAHTT | |
| SCHEMBL31376140 | 0.71 | TLR8 (0.50) | KCNH2GRM5HCAR1NOTUM | |
| SCHEMBL28240610 | 0.70 | KCNH2 (0.38) | KCNH2GRM5HCAR1CYP11B2NOTUM | |
| SCHEMBL8047156 | 0.66 | HCAR1 (0.42) | KCNH2HCAR1CYP11B2NOTUMLMNA | |
| SCHEMBL4959137 | 0.64 | LMNA (0.38) | KCNH2GRM5HCAR1CYP11B2LMNA | |
| SCHEMBL10691328 | 0.62 | POLB (0.41) | — | |
| SCHEMBL28197166 | 0.61 | CYP2D6 (0.43) | KCNH2HCAR1CYP11B2LMNA | |
| SCHEMBL5173711 | 0.60 | IDO1 (0.49) | KCNH2HCAR1CYP11B2NOTUMLMNA | |
| SCHEMBL7633090 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL11260141 | 0.59 | KCNH2 (0.39) | KCNH2GRM5HCAR1CYP11B2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4732989-A | INTERMEDIATES FOR BACTERICIDES | G. D. SEARLE & CO. (US) | 1988-03-22 | — | — | US | disclosed |
| US-4661602-A | ANTIANAEROBIC AGENTS | G. D. SEARLE & CO. (US) | 1987-04-28 | — | — | US | disclosed |