SCHEMBL10691288

SCHEMBL10691288

[CH2]c1c(C)cccc1N(S)C(=O)NC(=O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.45
HPGD P15428 3/20 0.41
POLB P06746 1/20 0.41
ALDH1A1 P00352 4/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
L3MBTL1 Q9Y468 2/20 0.38
KCNK3 O14649 1/20 0.38
KCNK9 Q9NPC2 1/20 0.38
NPC1 O15118 5/20 0.38
RAB9A P51151 5/20 0.38
NPSR1 Q6W5P4 2/20 0.38
MAPT P10636 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ALOX12 P18054 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11364582 0.76 GAA (0.44) EPHX1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL9686484 0.73 SIGMAR1 (0.32) HPGDPOLBALDH1A1MEN1KMT2A
SCHEMBL6118218 0.73 EPHX1 (0.58) EPHX1HPGDALDH1A1L3MBTL1NPC1
SCHEMBL10626822 0.73 TDP1 (0.47) EPHX1ALDH1A1L3MBTL1NPC1RAB9A
SCHEMBL27456060 0.71 EPHX1 (0.46) EPHX1HPGDPOLBALDH1A1SMN1; SMN2
SCHEMBL9686610 0.71 EPHX1 (0.76) EPHX1HPGDPOLBALDH1A1SMN1; SMN2
SCHEMBL5713603 0.71 ALDH1A1 (0.44) HPGDPOLBALDH1A1SMN1; SMN2L3MBTL1
SCHEMBL3314906 0.71 HDAC1 (0.40) POLBALDH1A1SMN1; SMN2L3MBTL1NPC1
SCHEMBL28014187 0.70 EPHX1 (0.44) EPHX1HPGDPOLBALDH1A1SMN1; SMN2
SCHEMBL11079112 0.70 MEN1 (0.46) ALDH1A1SMN1; SMN2KCNK3KCNK9NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0268989-A1 Imidazopyridine compounds and processes for preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-06-01 EP claimed
EP-0268989-A1 Imidazopyridine compounds and processes for preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1988-06-01 EP disclosed