Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29492473 | 0.86 | PBRM1 (0.88) | NPC1PBRM1ALDH1A1LMNAPOLB | |
| SCHEMBL203373 | 0.86 | PBRM1 (0.88) | NPC1PBRM1ALDH1A1LMNAPOLB | |
| SCHEMBL9097509 | 0.86 | PBRM1 (0.88) | NPC1PBRM1ALDH1A1LMNAPOLB | |
| SCHEMBL1072468 | 0.84 | HPGD (0.72) | HPGDNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7456273 | 0.84 | MAPT (0.70) | HPGDNPC1RAB9APBRM1MAPT | |
| SCHEMBL6654680 | 0.83 | HPGD (0.56) | HPGDNPC1RAB9APBRM1MAPT | |
| SCHEMBL17744847 | 0.82 | PBRM1 (0.81) | HPGDNPC1PBRM1ALDH1A1LMNA | |
| SCHEMBL5114913 | 0.82 | PBRM1 (0.81) | HPGDNPC1PBRM1ALDH1A1LMNA | |
| SCHEMBL5832368 | 0.82 | PBRM1 (0.81) | HPGDNPC1PBRM1ALDH1A1LMNA | |
| SCHEMBL29037240 | 0.82 | PBRM1 (0.81) | HPGDNPC1PBRM1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4783472-A | 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1988-11-08 | — | — | US | disclosed |