Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10611564 | 0.96 | PDGFRB (0.48) | PDE2APDGFRBPDGFRACYP3A4CYP1A2 | |
| SCHEMBL10685926 | 0.92 | PDGFRB (0.48) | PDE2APDGFRBPDGFRACYP3A4CYP2C19 | |
| SCHEMBL10690574 | 0.85 | PDE2A (0.51) | PDE2ACYP3A4CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL10690322 | 0.85 | PDGFRB (0.43) | PDGFRBPDGFRACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL10692316 | 0.85 | PDGFRB (0.43) | PDGFRBPDGFRACYP3A4CYP2C19CYP2D6 | |
| SCHEMBL10686088 | 0.84 | PDGFRB (0.47) | PDE2APDGFRBPDGFRACYP3A4CYP2C19 | |
| SCHEMBL10691792 | 0.83 | PDE2A (0.56) | PDE2APDGFRBPDGFRACYP3A4CYP1A2 | |
| SCHEMBL10686647 | 0.79 | PDE2A (0.42) | PDE2ACYP3A4CYP1A2CYP2C19TSHR | |
| SCHEMBL10611572 | 0.79 | PDE2A (0.51) | PDE2APDGFRBPDGFRAMAPTKDM4E | |
| SCHEMBL10964222 | 0.78 | CYP1A2 (0.39) | PDGFRBPDGFRACYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |