2,3,7,8-Tetrachlorodibenzo-P-Dioxin

SCHEMBL10692049

C1=Cc2ccccc2OO1.C1=Cc2ccccc2OO1.Clc1cc2c(cc1Cl)Oc1cc(Cl)c(Cl)cc1O2

nearest known ligand 0.45

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	AHR	P35869	16/20	0.45

▸	FLT1	P17948	1/20	0.45

▸	KDM4E	B2RXH2	1/20	0.39

▸	MEN1	O00255	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	MAPT	P10636	1/20	0.39

▸	KMT2A	Q03164	1/20	0.39

▸	TRPA1	O75762	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL121645	0.83	KDM4E (0.36)	KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL2965295	0.83	KDM4E (0.36)	KDM4EMEN1ALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL8071921	0.81	KDM4E (0.35)	KDM4EMEN1ALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL11520833	0.81	KDM4E (0.35)	KDM4EMEN1ALDH1A1MAPTKMT2A
Cyclohexane SCHEMBL23674788	0.77	KDM4E (0.33)	KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL3096913	0.74	AHR (0.72)	AHRFLT1
2,3,7,8-Tetrachlorodibenzo-P-Dioxin SCHEMBL10692053	0.74	AHR (0.72)	AHRFLT1
SCHEMBL23674717	0.70	LMNA (0.36)	—
SCHEMBL8029525	0.68	CTSD (0.33)	KDM4EMEN1ALDH1A1MAPTKMT2A
2,3,7,8-Tetrachlorodibenzo-P-Dioxin SCHEMBL7159644	0.67	AHR (0.59)	AHRFLT1KDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0259073-A2	Antibody-based bioassays for enzyme-inducing chemicals	WESTINGHOUSE ELECTRIC CORPORATION (US)	1988-03-09	—	—	EP	claimed