SCHEMBL10692275

SCHEMBL10692275

N#Cc1cc(N)ccc1S(=O)(=O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.57
HPGD P15428 3/20 0.57
LMNA P02545 3/20 0.57
KDM4E B2RXH2 7/20 0.52
ABCC9 O60706 2/20 0.49
ABCC8 Q09428 2/20 0.49
KCNJ11 Q14654 2/20 0.49
KCNJ8 Q15842 2/20 0.49
HTR6 P50406 3/20 0.47
MAPT P10636 1/20 0.46
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD11B1 P28845 1/20 0.42
GAA P10253 1/20 0.40
PKM P14618 1/20 0.40
HKDC1 Q2TB90 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9713772 0.90 HTR6 (0.50) ALDH1A1HPGDLMNAKDM4EABCC9
SCHEMBL12550087 0.86 KDM4E (0.47) ALDH1A1HPGDLMNAKDM4EHTR6
SCHEMBL20379715 0.81 NAMPT (0.47) ALDH1A1HPGDLMNAKDM4EABCC9
SCHEMBL4159366 0.80 HSD11B1 (0.57) ALDH1A1HPGDLMNAKDM4EABCC9
SCHEMBL1146161 0.79 HSD11B1 (0.59) ALDH1A1HPGDLMNAKDM4EABCC9
SCHEMBL6401042 0.79 ALDH1A1 (0.62) ALDH1A1HPGDLMNAKDM4EABCC9
SCHEMBL25176129 0.78 KDM4E (0.46) ALDH1A1HPGDLMNAKDM4EMAPT
SCHEMBL1162839 0.78 HTR6 (0.66) ALDH1A1HPGDLMNAKDM4EHTR6
SCHEMBL29480329 0.78 HTR6 (0.66) ALDH1A1HPGDLMNAKDM4EHTR6
SCHEMBL28507458 0.76 GAA (0.47) ALDH1A1HPGDLMNAKDM4EABCC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4754024-A Fibre-reactive azo dyes containing vinylsulfonyl or analogous groups CIBA-GEIGY CORPORATION 1988-06-28 US disclosed
EP-0112285-B1 REACTIVE DYES, THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1987-03-18 EP disclosed
EP-0112285-A2 Reactive dyes, their preparation and their use CIBA-GEIGY AG (CH) 1984-06-27 EP disclosed