Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 2/20 | 0.54 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989558 | 0.95 | NPC1 (0.56) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL5144037 | 0.88 | NPC1 (0.71) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL4242009 | 0.86 | NPC1 (0.59) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL10694289 | 0.84 | ALDH1A1 (0.57) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL10693233 | 0.80 | RNF4 (0.64) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL10693054 | 0.80 | NPC1 (0.52) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL23784723 | 0.77 | NPC1 (0.67) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL5452605 | 0.76 | NPC1 (1.00) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL3053543 | 0.75 | TSHR (0.59) | HTTRAB9ANPC1ALDH1A1PAX8 | |
| SCHEMBL5144036 | 0.74 | ALDH1A1 (0.71) | HTTRAB9ANPC1ALDH1A1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | claimed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | claimed |
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4518789-A | Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use | YU RUEY J | 1985-05-21 | — | — | US | disclosed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | disclosed |