Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 17/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692573 | 0.95 | HTT (0.61) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL5144037 | 0.84 | NPC1 (0.71) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL4242009 | 0.82 | NPC1 (0.59) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL10694289 | 0.80 | ALDH1A1 (0.57) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL10693233 | 0.77 | RNF4 (0.64) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL10693054 | 0.76 | NPC1 (0.52) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL3124943 | 0.76 | LTB4R2 (0.54) | NPC1LTB4R2 | |
| SCHEMBL23784723 | 0.74 | NPC1 (0.67) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL5452605 | 0.73 | NPC1 (1.00) | NPC1ALDH1A1GLAHTTRAB9A | |
| SCHEMBL14706246 | 0.72 | LTB4R2 (0.87) | LTB4R2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946495-A4 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0946495-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024756-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |