Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | PTPRB | P23467 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.44 |
| ▸ | RNF4 | P78317 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676729 | 0.90 | ALDH1A1 (0.59) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10694263 | 0.88 | CNR2 (0.54) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10695458 | 0.87 | PTGIR (0.52) | NPC1ALDH1A1RAB9APAX8SMN1; SMN2 | |
| SCHEMBL10689083 | 0.86 | HTT (0.49) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10693518 | 0.85 | RNF4 (0.58) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL11794701 | 0.80 | ALDH1A1 (0.45) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10692573 | 0.80 | HTT (0.61) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10693786 | 0.80 | LMNA (0.49) | NPC1ALDH1A1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL4242009 | 0.79 | NPC1 (0.59) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL10694467 | 0.78 | GAA (0.54) | NPC1ALDH1A1HTTRAB9APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | claimed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | claimed |
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4518789-A | Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use | YU RUEY J | 1985-05-21 | — | — | US | disclosed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | disclosed |