Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691485 | 0.81 | POLB (0.39) | HCRTR1TP53MAPTALOX15MAPK1 | |
| SCHEMBL10686121 | 0.81 | ATP4A (0.46) | HCRTR1TP53MAPTALOX15MAPK1 | |
| Iodide SCHEMBL10692587 | 0.77 | CYP1A2 (0.33) | HCRTR1TP53MAPTALOX15MAPK1 | |
| Iodide SCHEMBL9747550 | 0.71 | ATP4A (0.47) | MAPK1 | |
| SCHEMBL10689744 | 0.70 | MAPT (0.46) | HCRTR1TP53MAPTALOX15MAPK1 | |
| Iodide SCHEMBL9746633 | 0.69 | ATP4A (0.55) | MAPK1 | |
| Iodide SCHEMBL9747136 | 0.69 | ATP4A (0.58) | MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL10694491 | 0.67 | SMN1; SMN2 (0.32) | HCRTR1TP53MAPTALOX15MAPK1 | |
| Iodide SCHEMBL10691067 | 0.65 | ATP4A (0.54) | MAPTMAPK1SMN1; SMN2 | |
| Iodide SCHEMBL9749389 | 0.65 | CYP3A4 (0.44) | TP53MAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738967-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| US-4686227-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-08-11 | — | — | US | disclosed |
| EP-0165545-A2 | Imidazoisoquinoline compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-27 | — | — | EP | disclosed |