Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112517 | 0.83 | KMT2A (0.64) | HTTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| Pyridine SCHEMBL28090680 | 0.81 | TP53 (0.61) | HTTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL181572 | 0.81 | CES2 (0.78) | ALDH1A1KMT2AMEN1POLBCES2 | |
| Methyl Alcohol SCHEMBL27717832 | 0.80 | TP53 (0.69) | HTTALDH1A1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL333455 | 0.79 | TP53 (0.73) | HTTALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL11715543 | 0.79 | LMNA (0.56) | HTTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8962468 | 0.79 | CES2 (0.75) | ALDH1A1KMT2AMEN1POLBCES2 | |
| SCHEMBL13862605 | 0.78 | MAPT (0.56) | HTTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15110923 | 0.78 | ALDH1A1 (0.52) | HTTKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11295596 | 0.78 | TP53 (0.71) | HTTALDH1A1SMN1; SMN2L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4783472-A | 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1988-11-08 | — | — | US | disclosed |