Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487943 | 0.94 | TRIM24 (0.37) | TRIM24TRIM33TSHRALDH1A1CA1 | |
| SCHEMBL2955886 | 0.88 | TSHR (0.35) | TRIM24TRIM33TSHRCRBN | |
| SCHEMBL8653782 | 0.82 | TSHR (0.39) | TSHRALDH1A1 | |
| Cyclohexane SCHEMBL4940109 | 0.71 | TRIM24 (0.38) | TRIM24TRIM33TSHRALDH1A1 | |
| SCHEMBL2822859 | 0.71 | — | — | |
| SCHEMBL30151463 | 0.68 | — | — | |
| SCHEMBL52082 | 0.68 | ALDH1A1 (0.35) | TRIM24TRIM33TSHRALDH1A1 | |
| SCHEMBL51257 | 0.68 | ALDH1A1 (0.35) | TRIM24TRIM33TSHRALDH1A1 | |
| SCHEMBL262924 | 0.67 | TSHR (0.36) | TSHR | |
| SCHEMBL1356077 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255012-A2 | Process for modifying the adhesion of electroless metal coatings or plastic materials | BAYER AG (DE) | 1988-02-03 | — | — | EP | disclosed |