SCHEMBL10693522

SCHEMBL10693522

COc1ccc(C(=O)c2ccc(N(C)c3ccc(C)cc3)cc2C(=O)O)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTC4S Q16873 9/20 0.60
LMNA P02545 2/20 0.51
MEN1 O00255 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
TSHR P16473 1/20 0.51
CYP2C19 P33261 1/20 0.51
KMT2A Q03164 1/20 0.51
ALDH1A1 P00352 1/20 0.48
NPC1 O15118 1/20 0.48
AKR1C3 P42330 2/20 0.48
MAPT P10636 2/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
AKR1C2 P52895 1/20 0.45
RAB9A P51151 1/20 0.45
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10690670 0.91 LTC4S (0.61) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL10531019 0.90 LTC4S (0.62) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL10532008 0.85 LTC4S (0.62) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL7848711 0.85 LMNA (0.64) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL4839307 0.84 NPC1 (0.58) LTC4SLMNAMEN1CYP1A2CYP2C19
SCHEMBL4838995 0.84 ALDH1A1 (0.66) LMNAMEN1CYP1A2CYP3A4TSHR
SCHEMBL12757181 0.84 LMNA (0.54) LMNAMEN1CYP1A2CYP3A4TSHR
SCHEMBL10605623 0.81 AKR1C3 (0.58) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL9312633 0.80 LMNA (0.64) LTC4SLMNAMEN1CYP1A2CYP3A4
SCHEMBL10692514 0.80 KMT2A (0.52) LTC4SLMNAMEN1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4748148-A Recording system utilizing phthalide derivatives as colorless chromogenic material NEW OJI PAPER CO., LTD. (JP) 1988-05-31 US disclosed
US-4641160-A Recording system utilizing phthalide derivatives as colorless chromogenic material KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1987-02-03 US disclosed
EP-0127203-A1 New phthalide derivatives, process for preparing the same and recording system utilizing the same as colourless chromogenic material KANZAKI PAPER MANUFACTURING CO., LTD (JP) 1984-12-05 EP disclosed
EP-0062544-A1 New phthalide derivatives, process for preparing the same and recording system utilizing the same as colourless chromogenic material KANZAKI PAPER MANUFACTURING COMPANY LIMITED (JP) 1982-10-13 EP disclosed