Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.46 |
| ▸ | PLD2 | O14939 | 3/20 | 0.46 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.42 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.42 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690442 | 0.89 | OPRM1 (0.52) | OPRM1PLD1PLD2 | |
| SCHEMBL10692072 | 0.84 | OPRM1 (0.54) | OPRM1PLD1PLD2 | |
| SCHEMBL10712205 | 0.84 | PLD1 (0.53) | OPRM1HTR1AADRA2ADRD2HTR2A | |
| SCHEMBL11251753 | 0.80 | OPRM1 (0.60) | OPRM1HTR1AADRA2ADRD2HTR2A | |
| SCHEMBL11258172 | 0.76 | OPRM1 (0.58) | OPRM1HTR1AADRA2ADRD2HTR2A | |
| SCHEMBL7709273 | 0.76 | OPRM1 (0.72) | OPRM1HTR1AADRA2ADRD2HTR2A | |
| SCHEMBL10694307 | 0.76 | OPRM1 (0.52) | OPRM1PLD1PLD2 | |
| SCHEMBL10694355 | 0.73 | OPRM1 (0.53) | OPRM1PLD1PLD2 | |
| SCHEMBL10692634 | 0.73 | ADRA1A (0.61) | OPRM1HTR1AADRA2ADRD2HTR2A | |
| SCHEMBL10692743 | 0.73 | PLD1 (0.53) | OPRM1PLD1PLD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791104-A | HYPOTENSIVE, ANTILIPEMIC, ANTIHROMBOTIC, ANTIHYPOXIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1988-12-13 | — | — | US | disclosed |
| WO-1987002359-A1 | DIHYDROBENZOTHIOPHENE AND THIOCHROMANE AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-04-23 | — | — | WO | disclosed |