Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676729 | 0.87 | ALDH1A1 (0.59) | ALDH1A1HTTNPC1GLARAB9A | |
| SCHEMBL10692515 | 0.86 | GAA (0.53) | GAATSHRLMNACYP3A4ALDH1A1 | |
| SCHEMBL10693889 | 0.81 | GAA (0.62) | GAATSHRLMNACYP3A4ALDH1A1 | |
| SCHEMBL22289326 | 0.81 | GAA (0.73) | GAATSHRLMNACYP3A4ALDH1A1 | |
| SCHEMBL10694263 | 0.79 | CNR2 (0.54) | GAAALDH1A1HTTNPC1GLA | |
| SCHEMBL10693054 | 0.78 | NPC1 (0.52) | LMNACYP3A4ALDH1A1HTTNPC1 | |
| SCHEMBL10689083 | 0.78 | HTT (0.49) | LMNAALDH1A1HTTNPC1GLA | |
| SCHEMBL11835262 | 0.77 | GAA (0.63) | GAATSHRLMNACYP3A4ALDH1A1 | |
| SCHEMBL10693518 | 0.77 | RNF4 (0.58) | ALDH1A1HTTNPC1GLARAB9A | |
| SCHEMBL10988833 | 0.77 | PDK1 (0.47) | GAATSHRCYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | disclosed |
| US-4518789-A | Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use | YU RUEY J | 1985-05-21 | — | — | US | disclosed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | disclosed |