Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737217 | 0.91 | GAA (0.66) | GAAL3MBTL1KMT2ATSHRMEN1 | |
| SCHEMBL1970942 | 0.82 | KMT2A (0.71) | GAAL3MBTL1KMT2ATSHRMEN1 | |
| SCHEMBL17779177 | 0.81 | TSHR (0.63) | GAAL3MBTL1KMT2ATSHRMEN1 | |
| SCHEMBL7570382 | 0.78 | TSHR (0.75) | GAAKMT2ATSHRMEN1KDM4E | |
| SCHEMBL4191121 | 0.78 | PTGES2 (0.69) | GAAL3MBTL1KMT2AMEN1PTGES2 | |
| SCHEMBL3791578 | 0.78 | TSHR (0.74) | GAAKMT2ATSHRMEN1KDM4E | |
| SCHEMBL28450939 | 0.78 | MEN1 (0.68) | KMT2AMEN1KDM4EPKMLMNA | |
| SCHEMBL11583362 | 0.78 | KDM4E (0.67) | GAAKMT2ATSHRMEN1KDM4E | |
| SCHEMBL11872858 | 0.77 | DDX3X (0.71) | GAAKMT2ATSHRMEN1KDM4E | |
| SCHEMBL1592846 | 0.76 | TSHR (0.71) | GAAKMT2ATSHRMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-19 | — | — | US | disclosed |
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-19 | — | — | US | disclosed |
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-19 | — | — | US | disclosed |
| EP-2456310-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | Vanderbilt University (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | GRM4, GRIK4, GRIA4 | GAA 4587/4885L3MBTL1 4686/4885KMT2A 1413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.