Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069465 | 0.91 | GAA (0.66) | GAAL3MBTL1KMT2AMEN1TSHR | |
| SCHEMBL13577033 | 0.83 | KMT2A (0.64) | KMT2AMEN1TSHRMAPTNPSR1 | |
| SCHEMBL10695037 | 0.83 | MEN1 (0.73) | GAAKMT2AMEN1TSHRKDM4E | |
| SCHEMBL3320242 | 0.83 | MAPT (0.73) | KMT2AMEN1MAPTNPSR1MAPK1 | |
| SCHEMBL1970942 | 0.82 | KMT2A (0.71) | GAAL3MBTL1KMT2AMEN1TSHR | |
| SCHEMBL17779177 | 0.81 | TSHR (0.63) | GAAL3MBTL1KMT2AMEN1TSHR | |
| SCHEMBL4191121 | 0.81 | PTGES2 (0.69) | GAAL3MBTL1KMT2AMEN1MAPT | |
| SCHEMBL13577027 | 0.80 | LMNA (0.62) | GAAL3MBTL1KMT2AMEN1TSHR | |
| SCHEMBL7570382 | 0.78 | TSHR (0.75) | GAAKMT2AMEN1TSHRPTGES2 | |
| SCHEMBL7557478 | 0.78 | CXCR2 (0.53) | GAAL3MBTL1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |
| EP-1064274-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047508-A1 | BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 1999-09-23 | — | — | WO | disclosed |