Cloprothiazole

Cloprothiazole

SCHEMBL1069474

Cc1ncsc1CCCCl

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.81
KMT2A Q03164 3/20 0.81
MEN1 O00255 2/20 0.81
KDM4E B2RXH2 2/20 0.81
LMNA P02545 1/20 0.81
CYP1A2 P05177 1/20 0.81
CYP2D6 P10635 1/20 0.81
CYP2C9 P11712 1/20 0.81
CYP2C19 P33261 1/20 0.81
CYP4F2 P78329 3/20 0.43
CYP4A11 Q02928 3/20 0.43
SLC6A3 Q01959 1/20 0.38
MAPT P10636 2/20 0.37
HPGD P15428 1/20 0.37
PDE8B O95263 1/20 0.36
KAT2B Q92831 1/20 0.36
MAPK1 P28482 2/20 0.36
ALOX15 P16050 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clomethiazole SCHEMBL35223 0.89
Clomethiazole SCHEMBL1606752 0.88 ALDH1A1 (0.96) ALDH1A1KMT2AMEN1KDM4ELMNA
SCHEMBL13630791 0.83 ALDH1A1 (0.62) ALDH1A1KMT2AMEN1KDM4ELMNA
SCHEMBL27090459 0.82 ALDH1A1 (0.60) ALDH1A1KMT2AMEN1KDM4ELMNA
Clomethiazole SCHEMBL28087788 0.81 ALDH1A1 (0.74) ALDH1A1KMT2AMEN1KDM4ELMNA
Butyl Chloride SCHEMBL28790542 0.81 ALDH1A1 (0.64) ALDH1A1KMT2AMEN1KDM4ELMNA
SCHEMBL859923 0.80
SCHEMBL24023361 0.80 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1KDM4ELMNA
SCHEMBL27019720 0.80 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1KDM4ELMNA
SCHEMBL9804114 0.79 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-0125759-B1 TOPICAL COMPOSITION OF ANTIBIOTICS FOR APPLICATION TO THE MUCOSA WARNER LAMBERT HOLLAND B.V. (NL) 1991-09-25 EP claimed
EP-0125759-A2 Topical composition of antibiotics for application to the mucosa WARNER LAMBERT HOLLAND B.V. (NL) 1984-11-21 EP claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-20210393855-A1 NEW HYDROGELS HAVING A SILYLATED STRUCTURE, AND METHOD FOR OBTAINING SAME UNIVERSITE DE MONTPELLIER (FR) 2021-12-23 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
EP-3320342-B1 NEW HYDROGELS HAVING A SILYLATED STRUCTURE, AND METHOD FOR OBTAINING SAME UNIV MONTPELLIER (FR) 2021-03-03 EP disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-20180200408-A1 NEW HYDROGELS HAVING A SILYLATED STRUCTURE, AND METHOD FOR OBTAINING SAME UNIVERSITE DE MONTPELLIER (FR) 2018-07-19 US disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
EP-0125759-B1 TOPICAL COMPOSITION OF ANTIBIOTICS FOR APPLICATION TO THE MUCOSA WARNER LAMBERT HOLLAND B.V. (NL) 1991-09-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180200408-A1 NEW HYDROGELS HAVING A SILYLATED STRUCTURE, AND METHOD FOR OBTAINING SAME ILK, CD44, VCL ALDH1A1 797/4885KMT2A 2206/4885MEN1 3902/4885
US-20210393855-A1 NEW HYDROGELS HAVING A SILYLATED STRUCTURE, AND METHOD FOR OBTAINING SAME ILK, CD44, VCL ALDH1A1 877/4885KMT2A 2221/4885MEN1 3985/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 ALDH1A1 4459/4885KMT2A 4411/4885MEN1 671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.