Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Clomethiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clomethiazole SCHEMBL1606752 | 0.98 | ALDH1A1 (0.96) | — | |
| Cloprothiazole SCHEMBL1069474 | 0.89 | ALDH1A1 (0.81) | — | |
| Clomethiazole SCHEMBL28087788 | 0.86 | ALDH1A1 (0.74) | — | |
| Clomethiazole SCHEMBL159364 | 0.85 | ALDH1A1 (0.72) | — | |
| Clomethiazole SCHEMBL28087659 | 0.82 | ALDH1A1 (0.68) | — | |
| Clomethiazole SCHEMBL7346645 | 0.82 | ALDH1A1 (0.68) | — | |
| SCHEMBL859923 | 0.82 | — | — | |
| SCHEMBL680649 | 0.80 | — | — | |
| SCHEMBL5871890 | 0.78 | — | — | |
| SCHEMBL259480 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5056 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507371-B1 | COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM | UNIV RUTGERS (US) | 2026-01-28 | — | — | EP | claimed |
| US-12521426-B2 | Methods and compositions for inhibiting glyoxalase 1 (GLO1) | PALMER ABRAHAM (US) | 2026-01-13 | — | — | US | claimed |
| US-20250367192-A1 | BICYCLIC COMPOUNDS AND METHODS FOR THEIR USE IN TREATING PITT HOPKINS SYNDROME | NEUREN PHARMACEUTICALS LTD (NZ) | 2025-12-04 | — | — | US | claimed |
| US-12472177-B2 | Bicyclic compounds and methods for their use in treating Pitt Hopkins syndrome | NEUREN PHARMACEUTICALS LIMITED (NZ) | 2025-11-18 | — | — | US | claimed |
| CN-120025976-A | Method for differentiating hematopoietic stem/progenitor cells into granulocytes | 苏州血霁生物科技有限公司 | 2025-05-23 | — | — | CN | claimed |
| US-20250163379-A1 | METHOD FOR DIFFERENTIATING HEMATOPOIETIC STEM/PROGENITOR CELLS INTO NK CELLS | HEMACELL BIOTECHNOLOGY INC. (CN) | 2025-05-22 | — | — | US | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| WO-2024249914-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DYSTONIA | DUKE UNIVERSITY (US) | 2024-12-05 | — | — | WO | claimed |
| US-12145981-B2 | Methods and compounds for the treatment or prevention of severe influenza | Poolbeg Pharma (UK) Limited (GB) | 2024-11-19 | — | — | US | claimed |
| CN-118786209-A | Method for differentiating hematopoietic stem/progenitor cells into NK cells | 苏州血霁生物科技有限公司 | 2024-10-15 | — | — | CN | claimed |
| EP-0722316-A1 | NEW EMULSION FORMULATION | Astra Aktiebolag (SE) | 1996-07-24 | — | — | EP | claimed |
| WO-1995009609-A1 | NEW EMULSION FORMULATION | ASTRA AKTIEBOLAG (SE) | 1995-04-13 | — | — | WO | claimed |
| US-5399572-A | Chlormethiazole in the treatment of neurodegeneration | AKTIEBOLAGET ASTRA (SE) | 1995-03-21 | — | — | US | claimed |
| EP-0458892-B1 | USE OF CHLORMETHIAZOLE IN THE MANUFACTURE OF A MEDICAMENT FOR THE PREVENTION AND/OR TREATMENT OF NEURODEGENERATION | ASTRA AB (SE) | 1994-06-15 | — | — | EP | claimed |
| EP-0364350-B1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INST RECH CHIM BIOLOG (FR) | 1994-01-12 | — | — | EP | claimed |
| EP-0546306-A1 | 5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation | Astra Aktiebolag (SE) | 1993-06-16 | — | — | EP | claimed |
| EP-0458892-A1 | USE OF CHLORMETHIAZOLE IN THE MANUFACTURE OF A MEDICAMENT FOR THE PREVENTION AND/OR TREATMENT OF NEURODEGENERATION. | ASTRA AB (SE) | 1991-12-04 | — | — | EP | claimed |
| WO-1990009174-A1 | USE OF CHLORMETHIAZOLE IN THE PREVENTION AND/OR TREATMENT OF NEURODEGENERATION | AKTIEBOLAGET ASTRA (SE) | 1990-08-23 | — | — | WO | claimed |
| EP-0005121-B1 | PROCESS FOR STABILISATION OF 4-METHYL-5-(2'-CHLORETHYL)-THIAZOL | PHARMACEUTICAL LICENCES COMPANY LTD. (CH) | 1982-10-13 | — | — | EP | claimed |
| US-4247702-A | WITH A SATURATED TRIGLYCERIDE | PHARMACEUTICAL LICENCES COMPANY LTD. (CH) | 1981-01-27 | — | — | US | claimed |