Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 7/20 | 0.37 |
| ▸ | CA12 | O43570 | 6/20 | 0.37 |
| ▸ | CA1 | P00915 | 6/20 | 0.37 |
| ▸ | CA2 | P00918 | 6/20 | 0.37 |
| ▸ | CA9 | Q16790 | 6/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL8370297 | 0.89 | ALDH1A1 (0.53) | ALDH1A1MMP2CA12CA1CA2 | |
| Biphenyl SCHEMBL11241682 | 0.83 | ALDH1A1 (0.61) | ALDH1A1SLC18A3 | |
| Biphenyl SCHEMBL1609089 | 0.83 | ALDH1A1 (0.61) | ALDH1A1SLC18A3 | |
| Biphenyl SCHEMBL4942278 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SLC18A3 | |
| Biphenyl SCHEMBL12497681 | 0.80 | ALDH1A1 (0.57) | ALDH1A1SLC18A3 | |
| Carbimide SCHEMBL28002161 | 0.80 | ALDH1A1 (0.67) | ALDH1A1 | |
| SCHEMBL29133211 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MMP2CA12CA1CA2 | |
| SCHEMBL29133239 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MMP2CA12CA1CA2 | |
| SCHEMBL29133230 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MMP2CA12CA1CA2 | |
| SCHEMBL29133237 | 0.78 | ALDH1A1 (0.47) | ALDH1A1MMP2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260833-A2 | Process for producing polyamide acid having siloxane bonds and polyimide having siloxane bonds and isoindoloquinazolinedione rings | HITACHI CHEMICAL COMPANY (JP) | 1988-03-23 | — | — | EP | disclosed |