Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696473 | 0.82 | LTA4H (0.39) | PDE5ALTA4HNPC1RAB9AL3MBTL1 | |
| SCHEMBL10695888 | 0.79 | LTA4H (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3969727 | 0.76 | BACE1 (0.45) | LTA4HNPC1RAB9AL3MBTL1HIF1A | |
| SCHEMBL10697815 | 0.75 | LTA4H (0.36) | LTA4HBACE1MKNK1MKNK2 | |
| SCHEMBL12413756 | 0.72 | POLB (0.46) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL10130691 | 0.70 | LTA4H (0.49) | LTA4HNPC1RAB9AKDM4EMAPT | |
| SCHEMBL1106477 | 0.69 | HIF1A (0.45) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL20664871 | 0.68 | HIF1A (0.44) | LTA4HNPC1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL23760241 | 0.67 | HIF1A (0.43) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL12132422 | 0.67 | LTA4H (0.46) | LTA4HNPC1RAB9AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254588-A1 | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same | TOKYO TANABE COMPANY LIMITED (JP) | 1988-01-27 | — | — | EP | claimed |