Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770726 | 0.81 | ALDH1A1 (0.56) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9770730 | 0.77 | TDP1 (0.50) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28345154 | 0.76 | ALPG (0.54) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28345289 | 0.71 | CYP1A2 (0.40) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6704339 | 0.70 | KDM4E (0.54) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL28345889 | 0.70 | MAPT (0.49) | SMN1; SMN2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL2427361 | 0.66 | CYP1A2 (0.49) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2944091 | 0.66 | KDM4E (0.47) | SMN1; SMN2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL10696645 | 0.65 | ALPG (0.53) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9829674 | 0.65 | MAPT (0.55) | SMN1; SMN2HPGDALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |