Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPG | P10696 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695873 | 0.76 | SMN1; SMN2 (0.44) | PKMSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11014615 | 0.75 | ALPG (0.60) | ALPGRAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL6704339 | 0.75 | KDM4E (0.54) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL30228813 | 0.74 | ALPG (0.62) | ALPGSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL28674789 | 0.74 | ALPG (0.62) | ALPGSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11249330 | 0.74 | ALPG (0.55) | ALPGNPC1RAB9AMAPTKDM4E | |
| SCHEMBL9770670 | 0.74 | ALPG (0.55) | ALPGSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9770730 | 0.73 | TDP1 (0.50) | PKMSMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL9770726 | 0.73 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9AMAPTKDM4E | |
| SCHEMBL11269027 | 0.73 | ALPG (0.70) | ALPGKDM4EHSD17B10LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |