Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345289 | 0.79 | CYP1A2 (0.40) | TDP1CYP1A2PKMSMN1; SMN2KDM4E | |
| SCHEMBL9770726 | 0.79 | ALDH1A1 (0.56) | TDP1CYP1A2ALOX15NPC1RAB9A | |
| SCHEMBL6704339 | 0.78 | KDM4E (0.54) | TDP1CYP1A2TP53NPC1RAB9A | |
| SCHEMBL28345889 | 0.78 | MAPT (0.49) | TDP1CYP1A2SMN1; SMN2POLBKDM4E | |
| SCHEMBL10695873 | 0.77 | SMN1; SMN2 (0.44) | TDP1CYP1A2PKMTP53NPC1 | |
| SCHEMBL16328033 | 0.75 | ALOX15 (0.48) | TDP1CYP1A2PKMTP53ALOX15 | |
| SCHEMBL9770674 | 0.73 | CYP1A2 (0.50) | TDP1CYP1A2PKMTP53ALOX15 | |
| SCHEMBL2427361 | 0.73 | CYP1A2 (0.49) | TDP1CYP1A2PKMSMN1; SMN2KDM4E | |
| SCHEMBL28351806 | 0.72 | KDM4E (0.67) | TDP1TP53SMN1; SMN2POLBKDM4E | |
| SCHEMBL9535141 | 0.71 | CYP1A2 (0.50) | TDP1CYP1A2PKMTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| US-5030727-A | Reacting an anthronilide derivative with a thiazole derivative or a fluorozuinazolone with a neucleophile | BASF AKTIENGESELLSCHAFT (DE) | 1991-07-09 | — | — | US | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |