Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411351 | 0.81 | NPC1 (0.61) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL10695954 | 0.79 | RAB9A (0.56) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL7676622 | 0.77 | HSD17B10 (0.40) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL103116 | 0.71 | RAB9A (0.61) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL9570481 | 0.71 | RAB9A (0.61) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL7675253 | 0.70 | NPC1 (0.65) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL7684449 | 0.70 | HRH3 (0.59) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL9570359 | 0.69 | KDM4E (0.59) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL9482343 | 0.68 | LTA4H (0.53) | LMNAHTT | |
| SCHEMBL9570110 | 0.67 | RAB9A (0.60) | MAPTKDM4ERAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791117-A | LOCAL ANTESTHETICS, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-12-13 | — | — | US | disclosed |