Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694215 | 0.87 | ELANE (0.46) | TDP1ADAMTS5MMP12ELANEALDH1A1 | |
| SCHEMBL10701198 | 0.86 | TNKS2 (0.44) | TDP1MEN1KMT2ATNKS2ALDH1A1 | |
| SCHEMBL10700232 | 0.84 | TNKS2 (0.43) | TDP1MEN1KMT2ATNKS2ALDH1A1 | |
| SCHEMBL10700273 | 0.84 | TNKS2 (0.43) | TDP1MEN1KMT2ATNKS2ALDH1A1 | |
| SCHEMBL10695087 | 0.83 | TNKS2 (0.44) | TDP1MEN1KMT2ATNKS2ALDH1A1 | |
| SCHEMBL10695278 | 0.81 | TNKS2 (0.48) | MEN1KMT2ATNKS2ADAMTS5ALDH1A1 | |
| SCHEMBL10696420 | 0.80 | ELANE (0.43) | TDP1MEN1KMT2AELANEALDH1A1 | |
| SCHEMBL10696048 | 0.79 | ELANE (0.44) | TDP1ADAMTS5ELANEALDH1A1CYP3A4 | |
| SCHEMBL17377477 | 0.75 | SCN9A (0.63) | TDP1ADAMTS5MMP12ELANEMAPT | |
| SCHEMBL13341352 | 0.74 | TDP1 (0.52) | TDP1MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |